Poster Presentation 14th Lorne Infection and Immunity 2024

How does rabies virus prevent the production of interferon? (#140)

Hudson A Smith 1 , Gregory W Moseley 1 , Stephen M Rawlinson 1 , Cassandra T David 1
  1. Microbiology, Monash University, Clayton, VIC, Australia
Publish consent withheld
  1. 1. Wiltzer L, Larrous F, Oksayan S, Ito N, Marsh GA, Wang LF, Blondel D, Bourhy H, Jans DA, Moseley GW. 2012. Conservation of a unique mechanism of immune evasion across the Lyssavirus genus. J Virol 86:10194-10199.
  2. 2. Brzózka K, Finke S, Conzelmann K-K. 2005. Identification of the rabies virus alpha/beta interferon antagonist: phosphoprotein P interferes with phosphorylation of interferon regulatory factor 3. J Virol 79:7673-7681.
  3. 3. Rieder M, Brzózka K, Pfaller CK, Cox JH, Stitz L, Conzelmann K-K. 2011. Genetic dissection of interferon-antagonistic functions of rabies virus phosphoprotein: inhibition of interferon regulatory factor 3 activation is important for pathogenicity. J Virol 85:842-852.
  4. 4. Masatani T, Ozawa M, Yamada K, Ito N, Horie M, Matsuu A, Okuya K, Tsukiyama-Kohara K, Sugiyama M, Nishizono A. 2016. Contribution of the interaction between the rabies virus P protein and I-kappa B kinase ϵ to the inhibition of type I IFN induction signalling. J Gen Virol 97:316-326.
  5. 5. Scrima N, Le Bars R, Nevers Q, Glon D, Chevreux G, Civas A, Blondel D, Lagaudrière-Gesbert C, Gaudin Y. 2023. Rabies virus P protein binds to TBK1 and interferes with the formation of innate immunity-related liquid condensates. Cell Rep 42:111949.
  6. 6. Wang Z, Yuan Y, Zhang Y, Zhang C, Sui B, Zhao J, Zhou M, Chen H, Fu ZF, Zhao L. 2022. Substitution of S179P in the Lyssavirus phosphoprotein impairs Its interferon antagonistic function. J Virol 96:e01125-22.