Many lung diseases are characterized by airway inflammation in conjunction with pathological tissue remodeling. There is growing recognition of the importance of type2 inflammation in tissue healing, with archetypal type2 cells thought to be integral to the tissue repair process. Moreover, the local extracellular matrix influences cell function in vivo, impacting the nature of the ensuing inflammatory response We have determined that this local environment provides directional cues that dictate movement of cells within the lung, and this impacts the course and magnitude of local tissue inflammation. This presentation will focus on the cellular and molecular interactions that govern development of inflammation and repair in the lung.